RESUMO
Sjögren's syndrome and ankylosing spondylitis can occur either alone or in conjunction with other disorders. We report on two patients who met criteria for both primary Sjögren's syndrome and ankylosing spondylitis. Class I and II histocompatibility phenotypes were strikingly similar in the two patients and are in favor of a chance association.
Assuntos
Síndrome de Sjogren/complicações , Espondilite Anquilosante/complicações , Adulto , Antígenos de Histocompatibilidade Classe I/análise , Antígenos de Histocompatibilidade Classe II/análise , Humanos , Masculino , Síndrome de Sjogren/imunologia , Síndrome de Sjogren/patologia , Espondilite Anquilosante/imunologia , Espondilite Anquilosante/patologiaRESUMO
Human parvovirus B19 has been incriminated in the genesis of hematologic, dermatologic, neurologic, and rheumatic disorders. We report four cases in which inflammatory rheumatic manifestations developed during the course of human parvovirus B19 infection documented by the presence of IgM and IgG antibodies. There was one case each of monoarthritis, oligoarthritis, polyarthritis, and enthesitis. Three patients had a favorable outcome under nonsteroidal antiinflammatory drug therapy, and one developed reflex sympathetic dystrophy syndrome. In patients with inflammatory rheumatic manifestations that do not fit any specific diagnosis, a careful family history can provide evidence suggesting human parvovirus B19 infection, which should be confirmed by tests for IgM and IgG antibodies.
Assuntos
Anticorpos Antivirais/análise , Infecções por Parvoviridae/complicações , Parvoviridae/imunologia , Doenças Reumáticas/etiologia , Adulto , Anti-Inflamatórios não Esteroides/uso terapêutico , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/diagnóstico , Infecções por Parvoviridae/tratamento farmacológico , Doenças Reumáticas/tratamento farmacológico , Doenças Reumáticas/fisiopatologiaRESUMO
Chronic eosinophilic pneumonia and Churg-Strauss syndrome are two uncommon conditions of unknown etiology that share similar pulmonary manifestations. Whereas chronic eosinophilic pneumonia mainly targets the lung, Churg-Strauss syndrome is a systemic diseases. We report three patients who developed Churg-Strauss syndrome about eight years after being diagnosed with chronic eosinophilic pneumonia. Hypereosinophilia and high IgE levels were present in both conditions. Elevation of IgA levels was consistently demonstrated at the time of the diagnosis of Churg-Strauss syndrome. IgA elevation may be useful as a marker for progression of chronic eosinophilic pneumonia to Churg-Strauss syndrome.
Assuntos
Síndrome de Churg-Strauss/etiologia , Eosinofilia Pulmonar/complicações , Adulto , Doença Crônica , Progressão da Doença , Feminino , Humanos , Imunoglobulina A/análise , Imunoglobulina E/análise , Masculino , Pessoa de Meia-Idade , Eosinofilia Pulmonar/sangue , Eosinofilia Pulmonar/diagnóstico por imagem , Radiografia Torácica , Tomografia Computadorizada por Raios XRESUMO
This case reports documents the progressive development of chronic interstitial cystitis during the overlapping process from rheumatoid arthritis to lupus. Concomitantly high titer antinuclear antibody with an anti-68 KD RNP pattern and other biological markers of lupus were observed in the blood. The symptoms dramatically improved under methotrexate therapy. The pathogenic mechanism is discussed.
